Craig G. Crandall, PhD; Wanpen Vongpatanasin, MD; Ronald G. Victor, MD
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Crandall C., Vongpatanasin W., Victor R.; Cocaine and Body Temperature Regulation. Ann Intern Med. 2002;137:855-856. doi: 10.7326/0003-4819-137-10-200211190-00018
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Published: Ann Intern Med. 2002;137(10):855-856.
We agree that responses associated with the dose of cocaine administered may be very different from those that occur with cocaine toxicity. However, others have shown that cocaine-induced elevations in core temperature are dose dependent (1, 2). Thus, it is reasonable to suggest that if greater doses of cocaine had been administered, cutaneous vasodilation, sweating, and heat perception may have been even more attenuated. Given that sedating agents decrease internal temperature even in resting healthy persons who do not use cocaine (3), it is not surprising that treatment with sedation agents attenuates the elevation in temperature and improves survival in the cited experimental studies of cocaine toxicity.
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