Thierry Poynard, MD, PhD; Mona Munteanu, MD; Vlad Ratziu, MD
The Editors welcome submissions for possible publication in the Letters section. Authors of letters should:
•Include no more than 300 words of text, three authors, and five references
•Type with double-spacing
•Send three copies of the letter, an authors' form signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter.
Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned.
Annals welcomes electronically submitted letters.
Poynard T, Munteanu M, Ratziu V. Truth Survival. Ann Intern Med. 2002;137:932. doi: 10.7326/0003-4819-137-11-200212030-00017
Download citation file:
Published: Ann Intern Med. 2002;137(11):932.
We agree that very old publications declared obsolete or false in the year 2000 could cause the duration of survival to be overestimated if they were in fact obsolete or false many years earlier. However, this risk for survival overestimation does not concern the true conclusions that represent 60% of events.
For each obsolete or false conclusion, we estimated the year in which it became obsolete or false. Most often it was 1980 for biochemical liver tests; 1980 for corticosteroid treatment of hepatitis; and 1990 for non-A, non-B hepatitis, γ-globulin studies, and studies of portal hypertension. A new survival analysis was performed by using this new estimate of survival duration. With this new estimate, there was a small decrease of truth survival at 50 years for the mean percentage (±SE) of studies without false or obsolete conclusions (22% ± 4% vs. 26% ± 4% with the fixed estimate) but no difference in the percentage of studies without false conclusions (52% ± 5% vs. 53% ± 5% with the fixed estimate). The conclusions and the factors associated or not associated with truth survival did not change.
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only