Alka M. Kanaya, MD; David Herrington, MD, MHS; Eric Vittinghoff, PhD; Feng Lin, MS; Deborah Grady, MD, MPH; Vera Bittner, MD, MSPH; Jane A. Cauley, DrPH; Elizabeth Barrett-Connor, MD
Kanaya AM, Herrington D, Vittinghoff E, Lin F, Grady D, Bittner V, et al. Glycemic Effects of Postmenopausal Hormone Therapy: The Heart and Estrogen/progestin Replacement Study: A Randomized, Double-Blind, Placebo-Controlled Trial. Ann Intern Med. 2003;138:1-9. doi: 10.7326/0003-4819-138-1-200301070-00005
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Published: Ann Intern Med. 2003;138(1):1-9.
In observational studies, postmenopausal hormone therapy has been associated with lower fasting glucose levels. No prospective, controlled trial has evaluated the effect of postmenopausal hormone therapy on the development of diabetes mellitus.
Among the 2029 women in the Heart and Estrogen/progestin Replacement Study who had coronary disease but no diabetes at baseline, 6.2% of those receiving 0.625 mg of conjugated estrogen plus 2.5 mg of medroxyprogesterone acetate and 9.5% of those receiving placebo developed diabetes.
Recommendations about combination postmenopausal hormone therapy should consider that for every 30 women treated for 4 years, therapy might prevent one case of diabetes.
Impaired fasting glucose was indicated by a serum glucose level of 6.0 to 6.9 µmol/L (110 to 125 mg/dL).
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