Pasquale Strazzullo, MD; Roberto Iacone; Licia Iacoviello, MD, PhD; Ornella Russo; Gianvincenzo Barba, MD; Paola Russo, BS; Andria D'Orazio; Antonio Barbato, MD; Francesco Paolo Cappuccio, MD, FRCP; Eduardo Farinaro, MD; Alfonso Siani, MD
Acknowledgments: The authors thank Dr. A. Scottoni, Dr. U. Candura, and Ms. M. Bartolomei for organizing and coordinating the fieldwork and the workers of the Olivetti factories for their cooperation. They also thank Drs. E. Ragone, F. Stinga, and L. Russo for fieldwork; Dr. Antonella Venezia for laboratory support; and Mrs. Rosanna Scala and Grazia Fanara for editorial assistance.
Grant Support: By funds from MURST (Italian Ministry of University and of Scientific and Technological Research COFIN, 1998 and 2000).
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Pasquale Strazzullo, MD, Department of Clinical and Experimental Medicine, Federico II University of Naples, via S. Pansini 5, 80131 Naples, Italy; e-mail, firstname.lastname@example.org.
Current Author Addresses: Drs. Strazzullo, Barbato, and Farinaro; Mr. Iacone; and Ms. O. Russo: Department of Clinical and Experimental Medicine, Federico II University of Naples, via S. Pansini 5, 80131 Naples, Italy.
Dr. Iacoviello and Ms. D'Orazio: Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, via Nazionale, Santa Maria Imbaro, 66030 Lanciano (Chieti), Italy.
Drs. Barba and Siani and Ms. P. Russo: Institute of Food Sciences, CNR, via Roma 52A/C, 83100 Avellino, Italy.
Dr. Cappuccio: St. Georges' Hospital Medical School, Cranmer Terrace, London SW17 ORE, United Kingdom.
Author Contributions: Conception and design: P. Strazzullo, R. Iacone, L. Iacoviello, F.P. Cappuccio, E. Farinaro, A. Siani.
Analysis and interpretation of the data: P. Strazzullo, R. Iacone, L. Iacoviello, O. Russo, G. Barba, P. Russo, F.P. Cappuccio.
Drafting of the article: P. Strazzullo, R. Iacone, O. Russo.
Critical revision of the article for important intellectual content: P. Strazzullo, L. Iacoviello, G. Barba, P. Russo, F.P. Cappuccio, E. Farinaro, A. Siani.
Final approval of the article: P. Strazzullo, L. Iacoviello, P. Russo, F.P. Cappuccio, E. Farinaro, A. Siani.
Provision of study materials or patients: P. Strazzullo, A. D'Orazio, A. Barbato.
Statistical expertise: G. Barba, F.P. Cappuccio, A. Siani.
Obtaining of funding: P. Strazzullo.
Administrative, technical, or logistic support: R. Iacone, L. Iacoviello, A. D'Orazio.
Collection and assembly of data: O. Russo, A. Barbato.
Strazzullo P., Iacone R., Iacoviello L., Russo O., Barba G., Russo P., D'Orazio A., Barbato A., Cappuccio F., Farinaro E., Siani A.; Genetic Variation in the Renin–Angiotensin System and Abdominal Adiposity in Men: The Olivetti Prospective Heart Study. Ann Intern Med. 2003;138:17-23. doi: 10.7326/0003-4819-138-1-200301070-00007
Download citation file:
Published: Ann Intern Med. 2003;138(1):17-23.
Human obesity is caused by the interaction of genetic predisposition and many environmental and lifestyle factors (1). Although the chromosomal location of a few putative major genes for human obesity has been identified (2-5), the presence of a greater number of minor genes involved in the process of adipogenesis or in the regulation of adipocyte metabolism probably engenders susceptibility to obesity (6). Polymorphism in several obesity candidate genes has been the subject of intensive investigation, but little attention has been paid to the genes encoding for components of the renin–angiotensin system. The products of these genes (angiotensinogen [AGT], angiotensin-converting enzyme [ACE], and angiotensin II type 1 [AT2R1] and type II [AT2R2] receptors) are expressed in the adipose tissue in animal models as well as in humans (7-10). Recent experimental studies suggest that adipose tissue in the renin–angiotensin system plays a role in adipocyte growth and differentiation through angiotensin II (11, 12). In addition, epidemiologic studies have reported associations between AGT plasma levels (13, 14), plasma renin activity (15, 16), plasma ACE activity (17), and body mass index (BMI).
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only