Anna Peeters, PhD; Jan J. Barendregt, PhD; Frans Willekens, PhD; Johan P. Mackenbach, MD, PhD; Abdullah Al Mamun, BSc(Hons), MSc; Luc Bonneux, MD, PhD; for NEDCOM, the Netherlands Epidemiology and Demography Compression of Morbidity Research Group*
Acknowledgments: The authors thank Caspar Looman, René Eijkemans, and Tommy Visscher for their contributions to the development of this study. The authors also thank the Framingham Heart Study coordinators for access to the original data set.
Grant Support: By grants from the Netherlands Heart Foundation (contract 98.138) and the Netherlands Organization for Scientific Research (contract 904-66-093), The Hague, the Netherlands.
Requests for Single Reprints: Anna Peeters, PhD, Department of Public Health, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, the Netherlands; e-mail, email@example.com.
Current Author Addresses: Drs. Peeters, Barendregt, Mackenbach, and Bonneux: Department of Public Health, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, the Netherlands.
Drs. Willekens and Al Mamun: Population Research Center, University of Groningen, PO Box 800, 9700 AV Groningen, the Netherlands.
Author Contributions: Conception and design: A. Peeters, J.P. Mackenbach, L. Bonneux.
Analysis and interpretation of the data: A. Peeters, J.J. Barendregt, J.P. Mackenbach, A. Al Mamun, L. Bonneux.
Drafting of the article: A. Peeters, L. Bonneux.
Critical revision of the article for important intellectual content: A. Peeters, J.J. Barendregt, J.P. Mackenbach, L. Bonneux.
Final approval of the article: A. Peeters, J.J. Barendregt, J.P. Mackenbach, L. Bonneux.
Provision of study materials or patients: A. Peeters.
Statistical expertise: J.J. Barendregt, F. Willekens, A. Al Mamun.
Obtaining of funding: J.J. Barendregt, J.P. Mackenbach, L. Bonneux.
Peeters A., Barendregt J., Willekens F., Mackenbach J., Mamun A., Bonneux L., ; Obesity in Adulthood and Its Consequences for Life Expectancy: A Life-Table Analysis. Ann Intern Med. 2003;138:24-32. doi: 10.7326/0003-4819-138-1-200301070-00008
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Published: Ann Intern Med. 2003;138(1):24-32.
The increasing prevalence of overweight and obesity, coupled with their associations with death, disability, and disease, has led to their identification as a major, potentially preventable cause of premature morbidity and death (1-9). However, it is difficult to estimate the public health impact of overweight and obesity because of complex interactions with age; smoking; and obesity-related risk factors, such as diabetes, hypertension, and lipid disorders (8, 10-12). The observed relationship between body mass index (BMI) and mortality has been described as J-shaped; mortality increases as a result of underweight, overweight, and obesity. However, preexisting illness and inadequate control of smoking may cause at least part of the increased mortality at very low weight (8).
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