Thomas A. Barringer, MD; Julienne K. Kirk, PharmD; Amy C. Santaniello, PharmD; Kristie Long Foley, PhD; Robert Michielutte, PhD
Barringer TA, Kirk JK, Santaniello AC, Foley KL, Michielutte R. Effect of a Multivitamin and Mineral Supplement on Infection and Quality of Life: A Randomized, Double-Blind, Placebo-Controlled Trial. Ann Intern Med. 2003;138:365-371. doi: 10.7326/0003-4819-138-5-200303040-00005
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Published: Ann Intern Med. 2003;138(5):365-371.
Forty percent of U.S. adults use vitamin and mineral supplements, yet evidence of the health benefits of these supplements is lacking. The purported benefits of supplements relate to the immune system.
In this randomized, controlled trial, participants taking multivitamin and mineral supplements reported fewer infections and days absent from work than participants taking placebo. The results were largely due to striking benefits in participants with type 2 diabetes mellitus.
Multivitamin and mineral supplements appear to reduce infections in people with type 2 diabetes mellitus, a group at risk for micronutrient deficiency.
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