Leena Sharma, MD; Dorothy D. Dunlop, PhD; September Cahue, BS; Jing Song, MS; Karen W. Hayes, PhD
Grant Support: By National Institutes of Health grant AR-30692, National Institutes of Health/National Center for Research Resources grant RR-00048, and the Arthritis Foundation.
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Leena Sharma, MD, Division of Rheumatology, Feinberg School of Medicine, Northwestern University Medical School, 300 East Superior Avenue, Tarry Building 3-715, Chicago, IL 60611.
Current Author Addresses: Dr. Sharma and Ms. Cahue: Department of Medicine, Feinberg School of Medicine, Northwestern University Medical School, 300 East Superior Avenue, Tarry Building 3-715, Chicago, IL 60611.
Dr. Dunlop and Ms. Song: Institute for Health Services Research and Policy Studies, Northwestern University, 339 East Chicago Avenue, Wieboldt Hall, Room 717, Chicago, IL 60611.
Dr. Hayes: Department of Physical Therapy and Human Movement Sciences, Northwestern University Medical School, 645 North Michigan Avenue, Suite 1100, Chicago, IL 60611.
Author Contributions: Conception and design: L. Sharma, S. Cahue, K.W. Hayes.
Analysis and interpretation of the data: L. Sharma, D.D. Dunlop, J. Song.
Drafting of the article: L. Sharma, S. Cahue.
Critical revision of the article for important intellectual content: L. Sharma, D.D. Dunlop, K.W. Hayes.
Final approval of the article: L. Sharma, D.D. Dunlop, K.W. Hayes.
Provision of study materials or patients: S. Cahue.
Statistical expertise: D.D. Dunlop, J. Song.
Obtaining of funding: L. Sharma.
Administrative, technical, or logistic support: L. Sharma, J. Song, K.W. Hayes.
Collection and assembly of data: L. Sharma, S. Cahue, K.W. Hayes.
Sharma L., Dunlop D., Cahue S., Song J., Hayes K.; Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees. Ann Intern Med. 2003;138:613-619. doi: 10.7326/0003-4819-138-8-200304150-00006
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Published: Ann Intern Med. 2003;138(8):613-619.
Knee osteoarthritis is responsible for more chronic disability in elderly persons than any other medical condition (1). Quadriceps strengthening is widely recommended for knee osteoarthritis (2, 3), based on cross-sectional studies identifying strength (maximal voluntary muscle force generation) as a correlate of physical function (4-8) and on trials, predominantly short term, suggesting that quadriceps strengthening reduces pain and improves function (9, 10).
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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