Michael J. Kovacs, MD, FRCPC; Marc Rodger, MD, FRCPC, MSc; David R. Anderson, MD, FRCPC, MSc; Beverly Morrow, RN; Gertrude Kells, BScN, RN; Judy Kovacs, RN; Eleanor Boyle, BSc; Philip S. Wells, MD, FRCPC, MSc
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Michael J. Kovacs, MD, FRCPC, Department of Hematology, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario N6A 4G5, Canada; e-mail, email@example.com.
Current Author Addresses: Dr. Kovacs, Ms. Morrow, Ms. Kovacs, and Ms. Boyle: Department of Hematology, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario N6A 4G5, Canada.
Drs. Rodger and Wells: Ottawa Hospital—Civic Campus, 1053 Carling Avenue, Ottawa, Ontario K1Y 4E9, Canada.
Dr. Anderson and Ms. Kells: Queen Elizabeth II Health Sciences Centre, 1278 Tower Road, Halifax, Nova Scotia B3H 2Y9, Canada.
Author Contributions: Conception and design: M.J. Kovacs, M. Rodger, D.R. Anderson, E. Boyle, P.S. Wells.
Analysis and interpretation of the data: M.J. Kovacs, M. Rodger, D.R. Anderson, P.S. Wells.
Drafting of the article: M.J. Kovacs, M. Rodger, P.S. Wells.
Critical revision of the article for important intellectual content: M.J. Kovacs, M. Rodger, D.R. Anderson, P.S. Wells.
Final approval of the article: M.J. Kovacs, M. Rodger, D.R. Anderson, B. Morrow, J. Kovacs, E. Boyle, P.S. Wells.
Provision of study materials or patients: M.J. Kovacs, M. Rodger, D.R. Anderson, G. Kells, P.S. Wells.
Statistical expertise: M. Rodger, E. Boyle, P.S. Wells.
Obtaining of funding: M. Rodger.
Administrative, technical, or logistic support: M.J. Kovacs, M. Rodger, D.R. Anderson, P.S. Wells.
Collection and assembly of data: M.J. Kovacs, M. Rodger, D.R. Anderson, B. Morrow, G. Kells, J. Kovacs, P.S. Wells.
A detailed description of the study methodology and patient flow is available in a trials bank at http://rctbank.ucsf.edu/Presenter?518. Annals does not maintain the trials bank.
Kovacs MJ, Rodger M, Anderson DR, Morrow B, Kells G, Kovacs J, et al. Comparison of 10-mg and 5-mg Warfarin Initiation Nomograms Together with Low-Molecular-Weight Heparin for Outpatient Treatment of Acute Venous Thromboembolism: A Randomized, Double-Blind, Controlled Trial. Ann Intern Med. 2003;138:714-719. doi: 10.7326/0003-4819-138-9-200305060-00007
Download citation file:
Published: Ann Intern Med. 2003;138(9):714-719.
The management of venous thromboembolism has improved substantially in the past 10 years. Conventional therapy consists of unfractionated or low-molecular-weight heparin for 5 to 7 days, together with oral anticoagulation with warfarin given for a minimum of 3 months (1, 2). Low-molecular-weight heparin facilitates outpatient treatment, and warfarin is usually initiated within 24 hours. Clinical trials have demonstrated that low-molecular-weight heparin may be safely discontinued after 5 days once the international normalized ratio (INR) has remained greater than 1.9 for 24 hours (2, 3).
Learn more about subscription options.
Register Now for a free account.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only