Peter C. Gøtzsche, MD
Disclaimer: The views expressed are those of the author and are not necessarily the views or the official policy of the Cochrane Collaboration.
Gøtzsche PC. Screening for Breast Cancer. Ann Intern Med. 2003;138:769-770. doi: 10.7326/0003-4819-138-9-200305060-00021
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Published: Ann Intern Med. 2003;138(9):769-770.
TO THE EDITOR:
Humphrey and colleagues (1) noted that misclassification of cause of death could change the direction of the results of the trials they examined. However, they argued that the reduction in rates of advanced breast cancer in the Two-County Study (which are not related to judgments on cause of death) is similar to the reduction in breast cancer mortality. The problem with this reasoning is that assessment of cause of death is unreliable and biased in favor of screening (2). This was recently confirmed. The 2002 overview of the Swedish trials (3) reported only a 10% reduction in breast cancer mortality for the Ö stergötland part of the Two-County Study, whereas the authors of the Two-County Study recently reported a 24% reduction (Table)(4).
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