Brian J. McMahon, MD; Thomas W. Hennessy, MD, MPH; J. Michael Bensler, MD; Dana L. Bruden, MS; Alan J. Parkinson, PhD; Julie M. Morris, BS; Alisa L. Reasonover, BS; Debby A. Hurlburt, BSN; Michael G. Bruce, MD, MPH; Frank Sacco, MD; Jay C. Butler, MD
McMahon BJ, Hennessy TW, Bensler JM, Bruden DL, Parkinson AJ, Morris JM, et al. The Relationship among Previous Antimicrobial Use, Antimicrobial Resistance, and Treatment Outcomes for Helicobacter pylori Infections. Ann Intern Med. 2003;139:463-469. doi: 10.7326/0003-4819-139-6-200309160-00008
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Published: Ann Intern Med. 2003;139(6):463-469.
Adverse effects of previous antibiotic use in patients with Helicobacter pylori infections are unclear.
This retrospective study examined relationships between resistant H. pylori infections and past antibiotic use in 125 Alaskan Native adults. Clarithromycin-resistant H. pylori isolates were common (prevalence, 30%) and were associated in a dose-response manner with previous use of macrolide antibiotics. Of patients with these resistant isolates, 77% had treatment failure with clarithromycin-based regimens.
Previous use of macrolide antibiotics is associated with increased risk for infection with clarithromycin-resistant H. pylori and increased risk for treatment failure with that antibiotic.
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Gastroenterology/Hepatology, Infectious Disease, Peptic Disease, H. Pylori.
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