Kin Wing Choi, MBChB, MRCP; Tai Nin Chau, MBBS, MRCP; Owen Tsang, MBChB, MRCP; Eugene Tso, MBBS, MRCP; Ming Chee Chiu, MBChB, MRCP; Wing Lok Tong, MBBS, MRCP; Po Oi Lee, MBBS, FRCR; Tak Keung Ng, MBBS, FRCPath; Wai Fu Ng, MBBS, FRCPath; Kam Cheong Lee, MBBS, FRCPath; William Lam, MBBS, FRCPA; Wai Cho Yu, MBBS, FCCP; Jak Yiu Lai, MBBS, FRCP; Sik To Lai, MBBS; the Princess Margaret Hospital SARS Study Group*
Few large studies have described the presentation and course of patients with laboratory-confirmed severe acute respiratory syndrome (SARS).
This retrospective study from a Hong Kong hospital found that most of the 227 patients with laboratory-confirmed SARS presented with fever (99%), chills (75%), myalgia (50%), pulmonary infiltrates (95%), and lymphopenia (70%). Some had cough (40%), shortness of breath (20%), and rales (20%). During hospitalization, half had diarrhea and one fourth required intensive care for respiratory failure. The 3-month mortality rate was 12%.
Some patients with SARS do not present with respiratory symptoms even though they have lung infiltrates.
. Patients older than 60 years of age compared with those 60 years of age or younger. . Patients who had serum lactate dehydrogenase ( ) levels greater than 3.8 µkat/L at presentation compared with those who had levels of 3.8 µkat/L or less.
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Choi KW, Chau TN, Tsang O, Tso E, Chiu MC, Tong WL, et al. Outcomes and Prognostic Factors in 267 Patients with Severe Acute Respiratory Syndrome in Hong Kong. Ann Intern Med. 2003;139:715-723. doi: 10.7326/0003-4819-139-9-200311040-00005
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Published: Ann Intern Med. 2003;139(9):715-723.
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