Hashem B. El-Serag, MD, MPH; Jessica A. Davila, PhD; Nancy J. Petersen, PhD; Katherine A. McGlynn, PhD
El-Serag HB, Davila JA, Petersen NJ, McGlynn KA. The Continuing Increase in the Incidence of Hepatocellular Carcinoma in the United States: An Update. Ann Intern Med. 2003;139:817-823. doi: 10.7326/0003-4819-139-10-200311180-00009
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Published: Ann Intern Med. 2003;139(10):817-823.
Incidence rates of hepatocellular carcinoma have been increasing in the United States.
This large, retrospective, population-based cohort study confirmed an almost 2-fold increase in the incidence of hepatocellular carcinoma from 1975 to 1998. Increases were seen in all ethnic groups and in most age groups after 40 years of age. Although black people and older people remained most at risk, the largest recent increase in rates (from 1995 to 1998) occurred in white men 45 to 54 years of age.
The incidence of hepatocellular carcinoma continues to increase rapidly in the United States, especially in white, middle-aged men.
Age-specific incidence rates are shown for consecutive 3-year periods between 1975 and 1998.
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Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology, Liver Cancer, Liver Disease.
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