Michael Haap, MD; Andreas Fritsche, MD; Heinz Joachim Mensing, MD; Hans-Ulrich Häring, MD; Michael Stumvoll, MD
Grant Support: In part by grants from the Deutsche Forschungsgemeinschaft DFG (Stu 192/3-1 and FR 1561/1-1) and the European Union (QLRT-1999-00674).
Haap M, Fritsche A, Mensing HJ, Häring H, Stumvoll M. Association of High Serum Ferritin Concentration with Glucose Intolerance and Insulin Resistance in Healthy People. Ann Intern Med. 2003;139:869-871. doi: 10.7326/0003-4819-139-10-200311180-00029
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Published: Ann Intern Med. 2003;139(10):869-871.
TO THE EDITOR:
Background: Increasing evidence points to an association between increased body iron storage and type 2 diabetes mellitus, even outside the context of hemochromatosis (1, 2). A small intervention study provided preliminary evidence that bloodletting, which resulted in 50% reduction of serum ferritin concentrations, improved glycemia and insulin sensitivity in patients with type 2 diabetes (3). However, interpretation of mechanistic studies in patients with overt type 2 diabetes mellitus are complicated because glycemic control itself influences serum ferritin concentrations (glycosylated ferritin has a longer serum half-life) and primary effects on insulin sensitivity or β-cell function can no longer be studied.
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