William M. Lee, MD; Anne Larson, MD; Robert Fontana, MD; George Ostapowicz, MD
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Lee WM, Larson A, Fontana R, Ostapowicz G. Acute Liver Failure in the United States. Ann Intern Med. 2003;139:1045-1046. doi: 10.7326/0003-4819-139-12-200312160-00024
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Published: Ann Intern Med. 2003;139(12):1045-1046.
Space did not permit us to expand on cases in which therapeutic doses of acetaminophen caused acute liver failure or to describe their particular features. The diagnosis for each case reported in our prospective trial was made by the site investigator, an experienced hepatologist, on the basis of standard criteria, including history of ingestion, plasma acetaminophen levels, and alanine aminotransferase levels exceeding 3500 U/L, as well as exclusion of other etiologies. History of ingestion may be inaccurate and difficult to obtain in patients whose mental status is altered, but ancillary information is usually available from family and from the referring hospital, where the patient may have been able to give a more detailed history.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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