Justin A. Ezekowitz, MBBCh; Finlay A. McAlister, MD; Paul W. Armstrong, MD
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Ezekowitz J., McAlister F., Armstrong P.; Defibrillators and Sudden Death. Ann Intern Med. 2003;139:W-85. doi: 10.7326/0003-4819-139-12-200312160-w2
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Published: Ann Intern Med. 2003;139(12):W-85.
We disagree with Dr. Cohn's assertion that MADIT II should not be incorporated into the clinical decision-making process and should thus have been excluded from our meta-analysis of implantable cardioverter defibrillators in patients at increased risk for sudden cardiac death. The presence of ventricular ectopic beats on a Holter monitor was initially an inclusion criterion for MADIT II. However, after 23 patients were recruited, the executive committee eliminated this criterion (1). Because those 23 patients represent less than 2% of the total enrolled sample in MADIT II, we believe their inclusion would only minimally influence interpretation of the trial's results.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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