Jennifer Fisher Wilson
Wilson JF. The Promise of Disease Proteomics: Faster Detection, Diagnosis, and Drug Development. Ann Intern Med. 2004;140:317-319. doi: 10.7326/0003-4819-140-4-200402170-00036
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Published: Ann Intern Med. 2004;140(4):317-319.
The world of proteins is complex and fast-moving. More than a million distinct proteins course the body. The type and number of proteins fluctuate continuously, depending, for example, on whether a person is asleep or awake, hungry or full, sick or healthy. Proteins constantly send messages, regulate cell division, influence tissue growth, transport oxygen, and block infection. In sum, they carry out all of the body's vital functions.
Until recently, acquiring a snapshot of every protein in the body at any one time—called a proteome—was considered impossible. But today, scientists are beginning to harness the power of microarray chips and other high-throughput technologies to do just that. The work is far more complex than mapping the genome, which only required deciphering the static, linear sequence of all of the nucleotides in the DNA, but it may also be far more important to understanding and treating human diseases.
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Emergency Medicine, Hematology/Oncology, Prevention/Screening.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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