Joanne M. Murabito, MD, ScM; Byung-Ho Nam, PhD; Ralph B. D'Agostino, PhD; Donald M. Lloyd-Jones, MD, ScM; Christopher J. O'Donnell, MD, MPH; Peter W.F. Wilson, MD
Grant Support: By the National Institutes of Health National Heart, Lung, and Blood Institute contract N01-HC-25195.
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Joanne M. Murabito, MD, ScM, Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702-5827; e-mail, Joanne@fram.nhlbi.nih.gov.
Current Author Addresses: Drs. Murabito, Lloyd-Jones, O'Donnell, and Wilson: Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702-5827.
Drs. Nam and D'Agostino: Boston University Statistics and Consulting Unit, 100 Cummington Street, Boston, MA 02215.
Author Contributions: Conception and design: J.M. Murabito, B.-H. Nam, R.B. D'Agostino Sr., D.M. Lloyd-Jones, C.J. O'Donnell, P.W.F. Wilson.
Analysis and interpretation of the data: J.M. Murabito, B.-H. Nam, R.B. D'Agostino Sr., D.M. Lloyd-Jones, C.J. O'Donnell, P.W.F. Wilson.
Drafting of the article: J.M. Murabito, C.J. O'Donnell, P.W.F. Wilson.
Critical revision of the article for important intellectual content: J.M. Murabito, B.-H. Nam, R.B. D'Agostino Sr., D.M. Lloyd-Jones, C.J. O'Donnell, P.W.F. Wilson.
Final approval of the article: J.M. Murabito, B.-H. Nam, R.B. D'Agostino Sr., D.M. Lloyd-Jones, C.J. O'Donnell, P.W.F. Wilson.
Provision of study materials or patients: J.M. Murabito, C.J. O'Donnell, P.W.F. Wilson.
Statistical expertise: B.-H. Nam, R.B. D'Agostino Sr., P.W.F. Wilson.
Obtaining of funding: R.B. D'Agostino Sr., C.J. O'Donnell.
Administrative, technical, or logistic support: C.J. O'Donnell.
Collection and assembly of data: C.J. O'Donnell, J.M. Murabito, P.W.F. Wilson.
Murabito J., Nam B., D'Agostino R., Lloyd-Jones D., O'Donnell C., Wilson P.; Accuracy of Offspring Reports of Parental Cardiovascular Disease History: The Framingham Offspring Study. Ann Intern Med. 2004;140:434-440. doi: 10.7326/0003-4819-140-6-200403160-00010
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Published: Ann Intern Med. 2004;140(6):434-440.
Although physicians use the family history in their assessment of cardiovascular disease risk, the accuracy of patient reports of family history is unknown.
Using Framingham Heart Study data spanning 2 generations, the authors compared participant reports of parental history with parents' health records. Specificity was high and sensitivity was low for all items.
A positive family history item is probably accurate. A negative family history item is often inaccurate.
A report of a positive family history confers an increased risk for cardiovascular disease and risk factors in first-degree relatives (1-10). Therefore, physicians use self-reported information about family history to infer the risk for cardiovascular disease in their patients, develop screening strategies, and target primary prevention efforts (11). Although most of the information about family history that is available to physicians is limited to individual patient reports of their family members' disease status, little is known about the accuracy of these reports. Previous work has largely evaluated a person's reported family history compared with the relatives' self-reported medical history (12).
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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