Kris V. Kowdley, MD
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Kowdley K.; High-Dose Vitamin C and Iron Overload. Ann Intern Med. 2004;140:846-847. doi: 10.7326/0003-4819-140-10-200405180-00030
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Published: Ann Intern Med. 2004;140(10):846-847.
Sardi implies that medicinal iron alone was responsible for hemochromatosis in our patient rather than vitamin C taken in excess of 15 g/d for more than a decade. Although we agree that it is unclear which of the 2 factors (medicinal iron or megadoses of vitamin C) may have been primarily responsible, we believe it is impossible to incriminate (or exclude) one of these agents as the cause of iron overload. In fact, our case report maintained that greatly increased iron absorption may have originated with the medicinal iron but was facilitated by the conversion of iron to Fe3+ by ascorbic acid in the duodenum.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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