Josefina Seow, BSc; Fook Tim Chew, PhD
The Editors welcome submissions for possible publication in the Letters section. Authors of letters should:
•Include no more than 300 words of text, three authors, and five references
•Type with double-spacing
•Send three copies of the letter, an authors' form signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter.
Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned.
Annals welcomes electronically submitted letters.
Seow J., Chew F.; Risk Factors for Helicobacter pylori Resistance. Ann Intern Med. 2004;140:931. doi: 10.7326/0003-4819-140-11-200406010-00018
Download citation file:
Published: Ann Intern Med. 2004;140(11):931.
TO THE EDITOR:
The study by McMahon and colleagues (1) showed the association between previous use of macrolide antibiotics and resistance of Helicobacter pylori to clarithromycin and metronidazole. Besides past antibiotic use, clinicians should also consider other risk factors, such as geographic location, age, ethnicity, and ulcer status. In the Surveillance of H. pylori Antimicrobial Resistance Partnership (SHARP) study (2), many risk factors were found to be associated with resistance to individual agents. Clarithromycin resistance was significantly associated with older age, female sex, and geographic region, and the highest resistance rates, 13.9% and 13.0%, occurred in the mid-Atlantic and northern region of the United States, respectively. In the multivariable model, metronidazole resistance was significantly associated with Asian ethnicity and female sex. Metronidazole resistance rates were 50% in women younger than 40 years of age, compared with 47% in women at least 40 years of age, 32.4% in men younger than 40 years of age, and 30.7% in men at least 40 years of age. Dual resistance to clarithromycin and metronidazole was significantly associated with female sex, older age, and ethnicity; Asians had the highest rate of dual resistance (8%).
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only