Lonnie B. Hanauer, MD
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Hanauer L.; Tolerability of Rofecoxib versus Naproxen. Ann Intern Med. 2004;140:1059. doi: 10.7326/0003-4819-140-12-200406150-00020
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Published: Ann Intern Med. 2004;140(12):1059.
TO THE EDITOR:
The article comparing rofecoxib with naproxen (1) appears to have been mistakenly published in the editorial pages of Annals rather than the advertising section, where it seems to belong. The article was supported by Merck & Co. and written by employees or consultants of Merck. In addition, requests for reprints go to Merck. All of this might be reasonable if the article included any new, fair, or reasonable information.
Selective cyclooxygenase-2 inhibitors (coxibs) as a subset of nonsteroidal anti-inflammatory drugs (NSAIDs) have been available for more than 5 years and are generally accepted as having less gastrointestinal (GI) toxicity than older NSAIDs, to some degree. This marginal advantage comes at considerable extra cost in most patients without extra risk factors, and a recent Annals article concluded that coxibs were not cost-effective (2).
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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