John M. Luce, MD
Potential Financial Conflicts of Interest: None disclosed.
Current Author Address: John M. Luce, MD, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, 1001 Potrero Avenue, Room 5 K1, San Francisco, CA 94110; e-mail, email@example.com.
Luce JM. Physicians Should Administer Low-Dose Corticosteroids Selectively to Septic Patients until an Ongoing Trial Is Completed. Ann Intern Med. 2004;141:70-72. doi: 10.7326/0003-4819-141-1-200407060-00019
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Published: Ann Intern Med. 2004;141(1):70-72.
Most physicians prefer administering therapies that have a physiologic rationale and proven benefit. We urgently need beneficial therapies for sepsis severe enough to cause shock, which is responsible for approximately 400 000 intensive care unit admissions and 200 000 deaths each year in the United States (1). In this issue, a meta-analysis by Minneci and colleagues (2) from the National Institutes of Health (NIH) concludes that low but not high doses of corticosteroids reduce mortality from septic shock and that we should administer these agents to all patients who have vasopressor-dependent sepsis. How the investigators reached these conclusions and why I agree with the first but not the second of them are the subjects of this editorial.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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