Sam T. Donta, MD; Charles C. Engel, MD, MPH; Joseph F. Collins, ScD; Joel B. Baseman, PhD; Lisa L. Dever, MD; Thomas Taylor, MD; Kathy D. Boardman, RPh; Lewis E. Kazis, ScD; Suzanne E. Martin; Rebecca A. Horney, BS; Annette L. Wiseman; Douglas S. Kernodle, MD; Raymond P. Smith, MD; Aldona L. Baltch, MD; Christine Handanos, MD; Brian Catto, MD; Luis Montalvo, MD; Michael Everson, PhD; Warren Blackburn, MD; Manisha Thakore, MD; Sheldon T. Brown, MD; Larry Lutwick, MD; Dorothy Norwood, MD; Jack Bernstein, MD; Catherine Bacheller, MD; Bruce Ribner, MD; L. W. Preston Church, MD; Kenneth H. Wilson, MD; Prabhakar Guduru, MD; Robert Cooper, MD; Joseph Lentino, MD; Richard J. Hamill, MD; Arnold B. Gorin, MD; Victor Gordan, MD; David Wagner, MD; Cliff Robinson, MD; Pierre DeJace, MD; Ronald Greenfield, MD; Lisa Beck, MD; Marvin Bittner, MD; H. Ralph Schumacher, MD; Fredric Silverblatt, MD; James Schmitt, MD; Edward Wong, MD; Margaret A.K. Ryan, MD, MPH; Javier Figueroa, MD; Christopher Nice, MD; John R. Feussner, MD, MPH; the VA Cooperative #475 Group
*Of these participants, 15 returned for the 12-month visit and had 12-month data for the Physical Component Summary score, while the remaining 28 were considered to have had treatment failure for the primary outcome measure. †Of these participants, 14 returned for the 12-month visit and had 12-month data for the Physical Component Summary score; treatment was considered to have failed in the remaining 35. GWVIs = Gulf War veterans' illnesses.
Error bars represent 95% CIs.
The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.
Steven L. Sparks
August 4, 2004
Gulf War-Possible Selenium or Selenoprotien Metabolism Deficiency
For over 3 years I have been researching the long lasting side effects of statin drugs, which parallel those symptoms of Gulf War Syndrome. I have discussed these similiarities by Dr. Beatrice Golomb and others.
I must disclose that I have no medical training. I have read and evaluated the medical records of over 1,400 previous statin users, along with reading some 15,000 medical journal articles in an attempt to help trace down the pathways. At one time I discussed the possibilities of Mycoplasmas with Dr. Golomb and Dr. Nicholson.
Currently I hypothesize that a Selenium deficiency is leading to hyperphenylalaninemia as there is a lack of free ascorbate to recycle the BH3 radical back to BH4. The lack of selenium appears to cause the anti- oxident system to become oxidized due to the lack of glutathione peroxidase and other elements. Two previous statin users, off for 2-3 years, both tested Low for Oxidized Glutathione to Reduced Glutathione(GSSG/GSH) equal to 1.0. These two individuals along with two other similiar individuals also tested Low for Carnitine, possibly due to mitochondrial dysfunction and CPT-II deficiency.
I feel the hyperphenylalinemia is causing low tyrosine, low norepinephrine, low epinephrine, low dopamine and low Beta2-Adrenoceptors.
The statin victims suffer from chronic fatigue, muscle pain and weakness, bouts of occassional raised CPK-especially with exercise, short term memory loss, inability to sleep, hard muscles and cramps(intracellular calcium), arthritis like swelling in the joints, polyneuropathy, autoimmune disorders similiar to lupus, depression, sticky platelets and neurodegenerative diseases similiar to ALS.
Those that seem to be most affected seem to have high triglycerides and many have hypothyroidism, both which could be signs of low selenium.
Donta ST, Engel CC, Collins JF, Baseman JB, Dever LL, Taylor T, et al. Benefits and Harms of Doxycycline Treatment for Gulf War Veterans' Illnesses: A Randomized, Double-Blind, Placebo-Controlled Trial. Ann Intern Med. 2004;141:85-94. doi: 10.7326/0003-4819-141-2-200407200-00006
Download citation file:
Published: Ann Intern Med. 2004;141(2):85-94.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only