Louise Pilote, MD, MPH, PhD; Michal Abrahamowicz, PhD; Eric Rodrigues, MSc; Mark J. Eisenberg, MD, MPH; Elham Rahme, PhD
Acknowledgments: The authors thank Hugues Richard and Roxane du Berger for statistical programming.
Grant Support: In part by The Canadian Institutes of Health Research (grant 93834). Dr. Pilote is funded by The Canadian Institutes of Health Research and holds a William Dawson Chair at McGill University. Dr. Abrahamowicz is a James McGill Professor at McGill University. Drs. Eisenberg and Rahme are funded by the Fonds de la Recherche en Santé du Québec (FRSQ).
Potential Financial Conflicts of Interest:Consultancies: E. Rahme (Pfizer, Merck & Co.); Grants received: E. Rahme (Pfizer, Merck & Co.).
Requests for Single Reprints: Louise Pilote, MD, MPH, PhD, Division of Clinical Epidemiology, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada; e-mail, email@example.com.
Current Author Addresses: Drs. Pilote, Abrahamowicz, Rodrigues, and Rahme: Division of Clinical Epidemiology, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada.
Dr. Eisenberg: Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital, Suite A-118, 3755 Côte-Ste-Catherine Road, Montreal, Quebec H3T 1EZ, Canada.
Author Contributions: Conception and design: L. Pilote, M.J. Eisenberg, E. Rahme.
Analysis and interpretation of the data: L. Pilote, M. Abrahamowicz, E. Rodrigues, M.J. Eisenberg, E. Rahme.
Drafting of the article: L. Pilote, M. Abrahamowicz, E. Rodrigues, M.J. Eisenberg.
Critical revision of the article for important intellectual content: L. Pilote, M. Abrahamowicz, M.J. Eisenberg, E. Rahme.
Final approval of the article: L. Pilote, M. Abrahamowicz, E. Rodrigues, M.J. Eisenberg, E. Rahme.
Statistical expertise: L. Pilote, M. Abrahamowicz, M.J. Eisenberg, E. Rahme.
Obtaining of funding: L. Pilote.
Administrative, technical, or logistic support: L. Pilote.
Collection and assembly of data: L. Pilote, E. Rodrigues.
Pilote L, Abrahamowicz M, Rodrigues E, Eisenberg MJ, Rahme E. Mortality Rates in Elderly Patients Who Take Different Angiotensin-Converting Enzyme Inhibitors after Acute Myocardial Infarction: A Class Effect?. Ann Intern Med. 2004;141:102-112. doi: 10.7326/0003-4819-141-2-200407200-00008
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Published: Ann Intern Med. 2004;141(2):102-112.
Do all angiotensin-converting enzyme (ACE) inhibitors similarly improve survival after myocardial infarction?
This retrospective study linked hospital and prescription data from 18 453 patients 65 years of age and older who were admitted to 109 Canadian hospitals for myocardial infarction in the late 1990s. Patients who filled prescriptions for ramipril had lower mortality rates within the first year of hospital discharge than did those who filled prescriptions for several other ACE inhibitors, including captopril, enalapril, fosinopril, and quinapril.
Although analyses controlled for multiple potential confounders, the authors could not adjust for unmeasured factors that might make the risk for death seem related to a particular ACE inhibitor.
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Cardiology, Emergency Medicine, Nephrology, Hypertension, Coronary Risk Factors.
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