Tracey McLaughlin, MD; Gerald Reaven, MD
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McLaughlin T., Reaven G.; Metabolic Markers of Insulin Resistance in Overweight Persons. Ann Intern Med. 2004;141:243-244. doi: 10.7326/0003-4819-141-3-200408030-00022
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Published: Ann Intern Med. 2004;141(3):243-244.
We are concerned that Dr. Rizvi feels our recent report will sidetrack and confuse health care professionals. Obviously, that was not our intent. The purpose of our analysis was to make the important clinical point that not all overweight or obese individuals are at equal risk for serious health consequences (1), particularly type 2 diabetes mellitus and CVD. Given this difference in risk, the current obesity epidemic, and the difficulty in achieving weight loss, we thought it would be helpful to describe a relatively simple way to identify the apparently healthy overweight or obese person who would benefit most from weight loss. We do not believe that it represents an “undue obsession” with insulin resistance for us to indicate that insulin resistance or compensatory hyperinsulinemia increases the risk for type 2 diabetes and CVD (2-4).
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