Federico Soriguer, PhD; Gemma Rojo-Martínez, PhD; Isabel Esteva de Antonio, PhD
Grant Support: By the IS Carlos III (PI021311, Red de Centros de Metabolismo y Nutrición C03/08) and Junta de Andalucía (191/00).
Soriguer F., Rojo-Martínez G., de Antonio I.; Coffee Consumption and Type 2 Diabetes Mellitus. Ann Intern Med. 2004;141:321-323. doi: 10.7326/0003-4819-141-4-200408170-00017
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Published: Ann Intern Med. 2004;141(4):321-323.
TO THE EDITOR:
Salazar-Martinez and colleagues' study (1) suggests that long-term coffee consumption is associated with a significantly lower risk for type 2 diabetes mellitus. In the Pizarra study, a cross-sectional study of 1226 randomly selected adults from a small town in Spain (2-4), persons who drank coffee at least once per day had a lower risk for diabetes mellitus and impaired glucose tolerance (odds ratio, 0.66 [95% CI, 0.48 to 0.92]; P = 0.02) than persons who drank coffee only occasionally, after adjustment for age, sex, obesity, and smoking. Persons who drank coffee daily and those who did not had similar mean baseline blood levels of glucose and insulin and a similar index of insulin resistance according to the homeostasis model assessment. However, 120 minutes after a standard oral glucose tolerance test (5), persons who drank coffee daily had lower mean levels (±sd) of both glucose (6.82 ± 1.97 mmol/L vs. 6.26 ± 1.62 mmol/L [122.92 ± 35.57 mg/dL vs. 112.71 ± 29.19 mg/dL]; P = 0.01) and insulin (407 ± 375 pmol/L vs. 304 ± 262 pmol/L; P < 0.001), after we adjusted the analysis of variance model for age, sex, and obesity (body mass index > 30 kg/m2). There was a statistically significant association between coffee intake and carbohydrate metabolism disorders, as classified according to the American Diabetes Association (5)(P < 0.001 for glucose and P = 0.04 for insulin 120 minutes after an oral glucose tolerance test).
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