John W. Eikelboom, MBBS; Andrew McQuillan, MBBS; Daniel J. Quinlan, MBBS
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Eikelboom JW, McQuillan A, Quinlan DJ. Low-Molecular-Weight Heparin for Pulmonary Embolism. Ann Intern Med. 2004;141:407-408. doi: 10.7326/0003-4819-141-5-200409070-00025
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Published: Ann Intern Med. 2004;141(5):407-408.
In the Discussion section of our paper, we stated that the number of outcome events was modest and that our meta-analysis therefore lacked statistical power to reliably detect clinically worthwhile differences in treatment effect between LMWH and unfractionated heparin. However, the pooled data presented in our paper reflect the totality of the currently available randomized evidence, and it is extremely unlikely that there will be further randomized trials comparing LMWH and unfractionated heparin for the initial treatment of pulmonary embolism. Therefore, our data are probably the best evidence that we will ever have concerning this question.
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