Jan P. Vandenbroucke, MD, PhD; Frits R. Rosendaal, MD, PhD
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Vandenbroucke J., Rosendaal F.; Factor V Leiden and Venous Thromboembolism. Ann Intern Med. 2004;141:484. doi: 10.7326/0003-4819-141-6-200409210-00024
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Published: Ann Intern Med. 2004;141(6):484.
TO THE EDITOR:
Juul and colleagues (1) reported the results of the Copenhagen City Heart Study, a Danish cohort study that followed 9253 individuals beginning in 1976. They found that risk for VTE was increased 3-fold among carriers of factor V Leiden (216 events and 43 carriers) (1). This relative risk was substantially lower than the 7-fold risk that we reported in a case–control study of 474 patients with thrombosis and 474 controls (92 and 14 carriers, respectively) (2). Juul and colleagues ascribe this difference to “ascertainment bias” and a preponderance of risk factors among patients with venous thrombosis.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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