Chung-Jyi Tsai, MD, ScD; Michael F. Leitzmann, MD, DrPH; Walter C. Willett, MD, DrPH; Edward L. Giovannucci, MD, ScD
Acknowledgments: The authors thank the participants of the Health Professionals Follow-up Study for their continued cooperation and participation. They also thank all the research staff in the study for their expert help.
Grant Support: By research grants (CA55075 and DK46200) from the National Institutes of Health.
Potential Financial Conflicts of Interest: None disclosed.
Corresponding Author: Chung-Jyi Tsai, MD, ScD, Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, 800 Rose Street, MN649, Lexington, KY 40536-0298; e-mail, email@example.com.
Current Author Addresses: Dr. Tsai: Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, 800 Rose Street, MN649, Lexington, KY 40536-0298.
Dr. Leitzmann: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892.
Drs. Willett and Giovannucci: Harvard Medical School, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115.
Author Contributions: Conception and design: C.-J. Tsai, M.F. Leitzmann, W.C. Willett, E.L. Giovannucci.
Analysis and interpretation of the data: C.-J. Tsai, M.F. Leitzmann, W.C. Willett, E.L. Giovannucci.
Drafting of the article: C.-J. Tsai, M.F. Leitzmann.
Critical revision of the article for important intellectual content: C.-J. Tsai, M.F. Leitzmann, W.C. Willett, E.L. Giovannucci.
Final approval of the article: C.-J. Tsai, M.F. Leitzmann, W.C. Willett, E.L. Giovannucci.
Provision of study materials or patients: M.F. Leitzmann, W.C. Willett.
Statistical expertise: C.-J. Tsai, M.F. Leitzmann, W.C. Willett, E.L. Giovannucci.
Obtaining of funding: W.C. Willett.
Administrative, technical, or logistic support: W.C. Willett.
Collection and assembly of data: M.F. Leitzmann, W.C. Willett, E.L. Giovannucci.
Tsai C, Leitzmann MF, Willett WC, Giovannucci EL. The Effect of Long-Term Intake of cis Unsaturated Fats on the Risk for Gallstone Disease in Men: A Prospective Cohort Study. Ann Intern Med. 2004;141:514-522. doi: 10.7326/0003-4819-141-7-200410050-00007
Download citation file:
Published: Ann Intern Med. 2004;141(7):514-522.
Some people believe that high dietary intakes of cis unsaturated fat decrease cholesterol gallstone disease.
This prospective, population-based study involving 45 756 middle-aged and older men found that during 14 years of follow-up, high compared with low intakes of both monounsaturated and polyunsaturated fatty acids were associated with fewer self-reported cases of symptomatic gallstone disease.
The study compared high and low intakes of fatty acids; it did not determine optimal amounts of unsaturated fat intake.
Long-term intake of high amounts of total dietary cis unsaturated fat seems to be associated with decreased risk for gallstone disease in men.
Learn more about subscription options.
Register Now for a free account.
Cardiology, Gastroenterology/Hepatology, Dyslipidemia, Coronary Risk Factors, Biliary Disorders.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only