Mattijs E. Numans, MD, PhD; Peter A. Bonis, MD; Joseph Lau, MD
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Numans M., Bonis P., Lau J.; Limitations of Gold Standards for Diagnosing Gastroesophageal Reflux Disease. Ann Intern Med. 2004;141:648-649. doi: 10.7326/0003-4819-141-8-200410190-00020
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Published: Ann Intern Med. 2004;141(8):648-649.
We agree with Dr. Shojania that our meta-analysis can be reasonably interpreted as reflecting the limitations of the currently accepted reference tests for GERD, a point we made in the introduction and in the Methods and Discussion sections. Considerable uncertainty clearly surrounds the optimal definition and diagnosis of GERD (1). Our meta-analysis provided a detailed understanding of the relationship between these various tests and the PPI test. We were able to better define sensitivity, specificity, and predictive values of the PPI test for GERD while delineating factors that affect test accuracy.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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