Francesco Franceschi, MD
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Franceschi F. Helicobacter pylori and Idiopathic Thrombocytopenic Purpura. Ann Intern Med. 2004;141:820. doi: 10.7326/0003-4819-141-10-200411160-00018
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Published: Ann Intern Med. 2004;141(10):820.
In our previous study (1), in 1998, we described improved platelet count in patients with ITP after the eradication of H. pylori infection. A few months later, we investigated the prevalence of CagA-positive strains of H. pylori in the same patients and found that all patients were infected by those strains (2). None of the patients received steroids after eradication of H. pylori infection in 1998 because they maintained high platelet levels.
We used the Dixon test in our previous study (1), and the disappearance of the antiplatelet antibodies was related to the negative results of this test after H. pylori eradication. However, because the Dixon test is unreliable, we also investigated the presence of anti–glycoprotein IIb/IIIa antibodies, which remained unchanged after eradication of H. pylori. The platelet lysates from patients and controls were prepared by following the procedure described in the letter, using fresh platelets.
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