Ronald Witteles, MD; Kelly Matsuda, PharmD; Michael B. Fowler, MB, FRCP
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Witteles R., Matsuda K., Fowler M.; B-Type Natriuretic Peptide Is Effective Therapy before Care. Ann Intern Med. 2004;141:895. doi: 10.7326/0003-4819-141-11-200412070-00032
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Published: Ann Intern Med. 2004;141(11):895.
Editor's Note:The lead author of the following Clinical Observation was one of a dozen Associates of the American College of Physicians selected to present a clinical vignette at the 2004 Annual Session in Philadelphia. We are proud to present this case report through a special arrangement with the Council of Associates of the College.
TO THE EDITOR:
Background: B-type natriuretic peptide (BNP) is an endogenous hormone secreted by the ventricular myocardium in response to increased wall stretch. Actions of BNP include diuresis, natriuresis, and vasodilatation of both the systemic and pulmonary vascular systems. Recombinant BNP (nesiritide) is given as a continuous intravenous infusion and is approved for treating heart failure exacerbations. Studies have shown the efficacy of short-term BNP infusions for acutely decompensated heart failure (1-3). Data on prolonged BNP infusions before cardiac transplantation are limited.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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