Kenneth J. Mukamal, MD, MPH, MA; Alberto Ascherio, MD, DrPH; Murray A. Mittleman, MD, DrPH; Katherine M. Conigrave, MD; Carlos A. Camargo, MD, DrPH; Ichiro Kawachi, MD, PhD; Meir J. Stampfer, MD, DrPH; Walter C. Willett, MD, DrPH; Eric B. Rimm, ScD
Grant Support: By National Institutes of Health grants AA00299, AA11181, HL35464, and CA55075.
Potential Financial Conflicts of Interest:Honoraria: E.B. Rimm.
Requests for Single Reprints: Kenneth J. Mukamal, MD, MPH, MA, Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, RO-114, Boston, MA 02215; e-mail, firstname.lastname@example.org.
Current Author Addresses: Dr. Mukamal: Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, RO-114, Boston, MA 02215.
Drs. Ascherio, Willett, and Rimm: Department of Nutrition, Harvard School of Public Health, Building II, 655 Huntington Avenue, Boston, MA 02115.
Dr. Mittleman: Beth Israel Deaconess Medical Center, 185 Pilgrim Road, Dea-301, Boston, MA 02215.
Dr. Conigrave: Drug and Alcohol Department, Royal Prince Albert Hospital, Missenden Road, Camperdown, NSW 2050, Australia.
Dr. Camargo: Department of Emergency Medicine, Massachusetts General Hospital, Clinics Building 397, 55 Fruit Street, Boston, MA 02114.
Drs. Kawachi and Stampfer: Department of Epidemiology, Harvard School of Public Health, Kresge Building, 677 Huntington Avenue, Boston, MA 02115.
Author Contributions: Conception and design: E.B. Rimm.
Analysis and interpretation of the data: K.J. Mukamal, C.A. Camargo Jr., I. Kawachi, M.J. Stampfer.
Drafting of the article: K.J. Mukamal, I. Kawachi.
Critical revision of the article for important intellectual content: K.J. Mukamal, A. Ascherio, M.A. Mittleman, K.M. Conigrave, C.A. Camargo Jr., I. Kawachi, M.J. Stampfer, W.C. Willett, E.B. Rimm.
Final approval of the article: K.J. Mukamal, C.A. Camargo Jr., M.J. Stampfer, E.B. Rimm.
Provision of study materials or patients: E.B. Rimm.
Statistical expertise: M.J. Stampfer.
Obtaining of funding: K.J. Mukamal, E.B. Rimm.
Collection and assembly of data: I. Kawachi, E.B. Rimm.
Mukamal KJ, Ascherio A, Mittleman MA, Conigrave KM, Camargo CA, Kawachi I, et al. Alcohol and Risk for Ischemic Stroke in Men: The Role of Drinking Patterns and Usual Beverage. Ann Intern Med. 2005;142:11-19. doi: 10.7326/0003-4819-142-1-200501040-00007
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Published: Ann Intern Med. 2005;142(1):11-19.
Past studies don't clearly show that alcohol consumption affects the risk for ischemic stroke.
This prospective cohort study involving 38 156 male health professionals followed for 14 years found that consuming more than 2 drinks daily was associated with an increased risk for ischemic stroke. Two drinks or fewer were not associated with increased risk. Consuming red wine, but not other beverage types, was associated with a lower risk.
The study had limited power to determine the precise drinking patterns that were associated with stroke risk.
These findings support public health recommendations to avoid consuming more than 2 drinks daily.
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