Delia Scholes, PhD; Thomas M. Hooton, MD; Pacita L. Roberts, MS; Kalpana Gupta, MD, MPH; Ann E. Stapleton, MD; Walter E. Stamm, MD
Acknowledgments: The authors thank the study participants and the study staff, Barbara Monsey, Jane Grafton, Margaret Farrell-Ross, Mildred Magner, Fae Neumann, Mona Varro, and Brittany Morgan, for their assistance with study protocols, study coordination, programming, data collection and management, and manuscript preparation.
Grant Support: By National Institute of Diabetes and Digestive and Kidney Diseases grants 1 PO DK53369 and K23 DK02660 (Dr. Gupta).
Potential Financial Conflicts of Interest:Consultancies: K. Gupta (Bayer Corp., Procter & Gamble, Ortho-McNeil), W.E. Stamm (Bayer Corp., Ortho-McNeil, Medimmune); Honoraria: T.M. Hooton (Bayer Pharmaceuticals), K. Gupta (Bayer Corp., Procter & Gamble, Ortho-McNeil), W.E. Stamm (Ortho-McNeil, Medimmune); Grants received: K. Gupta (Procter & Gamble).
Requests for Single Reprints: Delia Scholes, PhD, Center for Health Studies, Group Health Cooperative, 1730 Minor Avenue, 16th Floor, Seattle, WA 98101; e-mail, firstname.lastname@example.org.
Current Author Addresses: Dr. Scholes: Center for Health Studies, Group Health Cooperative, 1730 Minor Avenue, 16th Floor, Seattle, WA 98101.
Dr. Hooton and Ms. Roberts: Harborview Medical Center, Box 359930, 325 Ninth Avenue, Seattle, WA 98105.
Dr. Gupta: Veterans Affairs Connecticut Healthcare System, 950 Campbell Avenue, 11-ACSLG, Building 2, West Haven, CT 06516.
Drs. Stapleton and Stamm: School of Medicine, University of Washington, Box 356523, 1959 Northeast Pacific Street, Seattle, WA 98195.
Author Contributions: Conception and design: D. Scholes, T.M. Hooton, K. Gupta, A.E. Stapleton, W.E. Stamm.
Analysis and interpretation of the data: D. Scholes, T.M. Hooton, P.L. Roberts, K. Gupta, A.E. Stapleton, W.E. Stamm.
Drafting of the article: D. Scholes, T.M. Hooton, W.E. Stamm.
Critical revision of the article for important intellectual content: D. Scholes, T.M. Hooton, P.L. Roberts, K. Gupta, A.E. Stapleton, W.E. Stamm.
Final approval of the article: D. Scholes, T.M. Hooton, P.L. Roberts, A.E. Stapleton, W.E. Stamm.
Provision of study materials or patients: D. Scholes, K. Gupta.
Statistical expertise: D. Scholes, P.L. Roberts.
Obtaining of funding: D. Scholes, A.E. Stapleton, W.E. Stamm.
Administrative, technical, or logistic support: W.E. Stamm.
Scholes D, Hooton TM, Roberts PL, Gupta K, Stapleton AE, Stamm WE. Risk Factors Associated with Acute Pyelonephritis in Healthy Women. Ann Intern Med. 2005;142:20-27. doi: 10.7326/0003-4819-142-1-200501040-00008
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Published: Ann Intern Med. 2005;142(1):20-27.
Little information is available about risk factors for pyelonephritis among healthy, community-dwelling women.
In a population-based case-control study of women with pyelonephritis 18 to 49 years of age, intercourse history variables, including frequency, new sexual partners, and spermicide use, were strongly associated with pyelonephritis. Personal and family histories of urinary tract infection, presence of diabetes, and stress incontinence were also associated with pylonephritis on multivariable analysis. Escherichia coli was the predominant infecting organism.
Risk factors for pyelonephritis were similar to those for acute and recurrent cystitis and asymptomatic bacteriuria, supporting the concept that pyelonephritis is usually caused by the ascent of organisms from the bladder.
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Infectious Disease, Nephrology, Urological Disorders, Urinary Tract Infection.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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