Edwin J. Whitney, MD; Richard A. Krasuski, MD; Bradley E. Personius, MD; Joel E. Michalek, PhD; Ara M. Maranian, MD; Mark W. Kolasa, MD; Erik Monick, MD; B. Gregory Brown, MD, PhD; Antonio M. Gotto, MD, DPhil
Disclaimer: The opinions expressed in this article are those of the authors, not the U.S. Air Force.
Acknowledgments: The authors thank Jennifer Palmer for her assistance with editing the manuscript.
Grant Support: By an unrestricted grant from the Parke Davis Branch of Pfizer Pharmaceuticals.
Potential Financial Conflicts of Interest: Consultancies: R.A. Krasuski (Pfizer Pharmaceuticals), A.M. Gotto Jr. (Pfizer Pharmaceuticals); Honoraria: R.A. Krasuski (Pfizer Pharmaceuticals), A.M. Gotto Jr. (Pfizer Pharmaceuticals, Kos Pharmaceuticals); Grants received: R.A. Krasuski (Pfizer Pharmaceuticals).
Requests for Single Reprints: Richard A. Krasuski, MD, U.S. Air Force Medical Center, 759 MSGS/MCCC, 2200 Bergquist Drive, Suite 1, Wilford Hall Medical Center, Lackland Air Force Base, TX; e-mail, Richard.email@example.com.
Current Author Addresses: Dr. Whitney: Heart and Vascular Institute of Texas, 1933 NE Loop 410, San Antonio, TX 78217.
Drs. Krasuski, Maranian, and Kolasa: 759 MSGS/MCCC, 2200 Bergquist Drive, Suite 1, Wilford Hall Medical Center, Lackland Air Force Base, TX 78236-5300.
Dr. Personius: Cardiology Consultants, 520 SW Ramsey Avenue, Suite 101, Grants Pass, OR 97526.
Dr. Michalek: University of Texas School of Public Health, 5323 Harry Hines Boulevard, V8.112M, Dallas, TX 75390-9128.
Dr. Monick: Department of Medicine, Northwestern University—The Feinberg School of Medicine, 251 East Huron Street, Galter Pavilion, Suite 3-150, Chicago, IL 60611.
Dr. Brown: Box 356422, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195-6422.
Dr. Gotto: Joan and Samuel Weill College of Medicine, Cornell University, 1300 New York Avenue, Box 5, New York, NY 10021.
Author Contributions: Conception and design: E.J. Whitney, B.G. Brown.
Analysis and interpretation of the data: E.J. Whitney, R.A. Krasuski, B.E. Personius, A.M. Maranian, M.W. Kolasa, E. Monick, B.G. Brown.
Drafting of the article: E.J. Whitney, R.A. Krasuski, B.E. Personius.
Critical revision of the article for important intellectual content: E.J. Whitney, R.A. Krasuski, B.E. Personius, A.M. Maranian, E. Monick, B.G. Brown, A.M. Gotto Jr.
Final approval of the article: E.J. Whitney, R.A. Krasuski, B.G. Brown, A.M. Gotto Jr.
Provision of study materials or patients: E.J. Whitney.
Statistical expertise: E.J. Whitney, R.A. Krasuski, J.E. Michalek.
Obtaining of funding: E.J. Whitney.
Administrative, technical, or logistic support: E.J. Whitney, R.A. Krasuski, A.M. Maranian.
Collection and assembly of data: E.J. Whitney, R.A. Krasuski, A.M. Maranian, M.W. Kolasa, E. Monick.
Whitney EJ, Krasuski RA, Personius BE, Michalek JE, Maranian AM, Kolasa MW, et al. A Randomized Trial of a Strategy for Increasing High-Density Lipoprotein Cholesterol Levels: Effects on Progression of Coronary Heart Disease and Clinical Events. Ann Intern Med. 2005;142:95-104. doi: 10.7326/0003-4819-142-2-200501180-00008
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Published: Ann Intern Med. 2005;142(2):95-104.
Most trials that address lipid management focus on reducing low-density lipoprotein (LDL) cholesterol levels rather than increasing high-density lipoprotein (HDL) cholesterol levels.
In this double-blind trial, 143 military retirees with low HDL cholesterol levels and coronary artery disease were randomly assigned to placebo or aggressive HDL cholesterol–increasing therapy with gemfibrozil, niacin, and cholestyramine for 30 months. All participants received diet and exercise counseling. Compared with the placebo group, the treated group had a 20% decrease in total cholesterol level; a 36% increase in HDL cholesterol level; less focal coronary stenosis; fewer total cardiovascular events; and more flushing, skin rashes, and abdominal symptoms.
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Cardiology, Dyslipidemia, Coronary Risk Factors, Coronary Heart Disease.
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