George Davey Smith, DSc; Yiscah Bracha, MS; Kenneth H. Svendsen, MS; James D. Neaton, PhD; Steven M. Haffner, MD; Lewis H. Kuller, MD; Multiple Risk Factor Intervention Trial Research Group*
This trial is registered as NCT00000487 on http://clinicaltrials.gov.
Acknowledgments: The authors acknowledge the efforts of the many MRFIT investigators who collected these data and the MRFIT Editorial Committee (Jerome D. Cohen, MD; Jeffrey A. Cutler, MD; Richard Grimm Jr., MD, PhD; Lewis H. Kuller, MD, DPH; James D. Neaton, PhD; Judith K. Ockene, PhD; Ronald Prineas, MD, PhD; and Jeremiah Stamler, MD). The authors thank Dr. Johan Eriksson for information about the percentage of participants who were smokers at baseline in the Finnish intervention study (9).
Grant Support: By National Heart, Lung, and Blood Institute grant R01-HL68140.
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: George Davey Smith, DSc, Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, United Kingdom; e-mail, firstname.lastname@example.org.
Current Author Addresses: Dr. Davey Smith: Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, United Kingdom.
Ms. Bracha: Berman Center for Outcomes and Clinical Research, Minneapolis Medical Research Foundation, 825 South Eighth Street, Suite 440, Minneapolis, MN 55404.
Mr. Svendsen and Dr. Neaton: Coordinating Centers for Biometric Research, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455.
Dr. Haffner: Division of Clinical Epidemiology, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284-7873.
Dr. Kuller: The Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261.
Author Contributions: Conception and design: G. Davey Smith, Y. Bracha, J.D. Neaton.
Analysis and interpretation of the data: G. Davey Smith, Y. Bracha, K.H. Svendsen, J.D. Neaton, L.H. Kuller.
Drafting of the article: G. Davey Smith, Y. Bracha, J.D. Neaton.
Critical revision of the article for important intellectual content: G. Davey Smith, K.H. Svendsen, J.D. Neaton, L.H. Kuller.
Final approval of the article: G. Davey Smith, Y. Bracha, J.D. Neaton, L.H. Kuller.
Statistical expertise: Y. Bracha, K.H. Svendsen, J.D. Neaton.
Obtaining of funding: J.D. Neaton.
Collection and assembly of data: J.D. Neaton.
Davey Smith G, Bracha Y, Svendsen KH, Neaton JD, Haffner SM, Kuller LH, et al. Incidence of Type 2 Diabetes in the Randomized Multiple Risk Factor Intervention Trial. Ann Intern Med. 2005;142:313-322. doi: 10.7326/0003-4819-142-5-200503010-00006
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Published: Ann Intern Med. 2005;142(5):313-322.
Weight loss and exercise decrease the development of diabetes in people with impaired glucose tolerance, but the effectiveness of these interventions in people with normal glucose tolerance is unknown.
Using data from a large randomized, controlled trial of cardiovascular disease prevention in men, the investigators show that participants with normal glucose tolerance at baseline developed diabetes at similar rates whether they received the diet and exercise intervention or usual care. However, the intervention was associated with lower risk of diabetes among nonsmokers.
While diet and exercise may reduce the development of diabetes in nonsmokers with normal glucose metabolism at baseline, this benefit was not apparent among smokers.
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Cardiology, Endocrine and Metabolism, Diabetes, Coronary Risk Factors.
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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