Shumin M. Zhang, MD, ScD; Julie E. Buring, ScD; I-Min Lee, MBBS, ScD; Nancy R. Cook, ScD; Paul M. Ridker, MD, MPH
Acknowledgments: The authors thank Marilyn Chown for her statistical analytic support, the staff of the Women's Health Study, and the 39 876 dedicated participants of the Women's Health Study.
Grant Support: By research grants CA-47988 and HL-43851 from the National Institutes of Health, with additional support from the Doris Duke Foundation and the Donald W. Reynolds Foundation. Dr. Zhang is supported in part by a National Cancer Institute Career Development Award (CA096619).
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Shumin M. Zhang, MD, ScD, Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston, MA 02215; e-mail, email@example.com.
Current Author Addresses: Drs. Zhang, Buring, Cook, Lee, and Ridker: Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston, MA 02215.
Author Contributions: Conception and design: S.M. Zhang, P.M. Ridker.
Analysis and interpretation of the data: S.M. Zhang, N.R. Cook, P.M. Ridker.
Drafting of the article: S.M. Zhang, P.M. Ridker.
Critical revision of the article for important intellectual content: S.M. Zhang, J.E. Buring, I.-M. Lee, N.R. Cook, P.M. Ridker.
Final approval of the article: S.M. Zhang, J.E. Buring, I.-M. Lee, N.R. Cook, P.M. Ridker.
Statistical expertise: S.M. Zhang, N.R. Cook, P.M. Ridker.
Obtaining of funding: J.E. Buring, P.M. Ridker.
Administrative, technical, or logistic support: S.M. Zhang, I.-M. Lee, P.M. Ridker.
Collection and assembly of data: S.M. Zhang, J.E. Buring, I.-M. Lee, P.M. Ridker.
Zhang SM, Buring JE, Lee I, Cook NR, Ridker PM. C-Reactive Protein Levels Are Not Associated with Increased Risk for Colorectal Cancer in Women. Ann Intern Med. 2005;142:425-432. doi: 10.7326/0003-4819-142-6-200503150-00008
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Published: Ann Intern Med. 2005;142(6):425-432.
Some data suggest that low-grade inflammation may play a role in the development of colorectal cancer.
In this 10-year prospective study involving 27 913 healthy women age 45 years or older, elevated C-reactive protein (CRP) levels at baseline were not associated with a higher likelihood of colorectal cancer.
A single baseline CRP measurement may be an imperfect marker of inflammation. The investigators relied on a woman's report of cancer rather than an ongoing surveillance protocol for colorectal lesions.
Low-grade inflammation may not be associated with in-creased colorectal cancer risk.
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Gastroenterology/Hepatology, Hematology/Oncology, Gastrointestinal Cancer, Colorectal Cancer, Prevention/Screening.
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