Neil A. Goldenberg, MD; Linda Jacobson, MT; Marilyn J. Manco-Johnson, MD
Acknowledgments: The authors thank Chris Bombardier for assistance in study coordination and Chris McKelvey and Sue Hurwitz for their technical expertise in performing the PFA-100 testing. They also thank William E. Hathaway, MD, and Philip Altus, MD, for valued commentary on the manuscript and the study participants for their contribution to this research.
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Neil Goldenberg, MD, The Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center, PO Box 6507, Mail Stop F416, Aurora, CO 80045-0507; e-mail, email@example.com.
Current Author Addresses: Dr. Goldenberg, Ms. Jacobson, and Dr. Manco-Johnson: Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center, PO Box 6507, Mail Stop F416, Aurora, CO 80045-0507.
Author Contributions: Conception and design: N.A. Goldenberg, L. Jacobson, M.J. Manco-Johnson.
Analysis and interpretation of the data: N.A. Goldenberg, L. Jacobson, M.J. Manco-Johnson.
Drafting of the article: N.A. Goldenberg, L. Jacobson.
Critical revision of the article for important intellectual content: N.A. Goldenberg, L. Jacobson, M.J. Manco-Johnson.
Final approval of the article: N.A. Goldenberg, L. Jacobson, M.J. Manco-Johnson.
Provision of study materials or patients: N.A. Goldenberg, M.J. Manco-Johnson.
Statistical expertise: N.A. Goldenberg.
Obtaining of funding: M.J. Manco-Johnson (local funding).
Administrative, technical, or logistic support: N.A. Goldenberg, L. Jacobson, M.J. Manco-Johnson.
Collection and assembly of data: N.A. Goldenberg, L. Jacobson.
Goldenberg N., Jacobson L., Manco-Johnson M.; Brief Communication: Duration of Platelet Dysfunction after a 7-Day Course of Ibuprofen. Ann Intern Med. 2005;142:506-509. doi: 10.7326/0003-4819-142-7-200504050-00009
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Published: Ann Intern Med. 2005;142(7):506-509.
The recommendation that patients discontinue using nonsteroidal anti-inflammatory drugs at least 1 week before surgery is common but not evidence-based.
This study evaluated platelet function in 11 healthy volunteers at baseline and 40 minutes, 8 hours, and 24 hours after the participants completed a 7-day course of 600 mg of ibuprofen every 8 hours. Platelet function was abnormal 40 minutes after the last dose of ibuprofen in 7 of the 11 patients and normal in all by 24 hours, suggesting that it may not be necessary to discontinue ibuprofen use until 24 hours before surgery.
This study evaluated platelet function in healthy adults using a platelet function analyzer and did not examine clinical bleeding.
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Hematology/Oncology, Platelet Disorders, Coagulopathies.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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