Pierre Delanaye, MD; Jean-Marie Krzesinski, MD
Potential Financial Conflicts of Interest: None disclosed.
Delanaye P., Krzesinski J.; The New Mayo Clinic Equation for Estimating Glomerular Filtration Rate. Ann Intern Med. 2005;142:679-680. doi: 10.7326/0003-4819-142-8-200504190-00029
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Published: Ann Intern Med. 2005;142(8):679-680.
TO THE EDITOR:
We read with great interest the article by Rule and colleagues (1) on the use of different creatinine-based equations to estimate GFR. We fully agree with the limitations of the MDRD equation for healthy persons. Nevertheless, we would like to make some comments. First, as Rule and colleagues mentioned, their new equation does not adequately represent elderly patients or persons of nonwhite ethnicity. We think that neither the MDRD equation nor the new proposed Mayo Clinic equation will be satisfactory in certain populations, including obese, anorexic, cirrhotic, or pediatric patients (2). In these populations, the relationship between serum creatinine and GFR is not the same as in normal-weight adults of white ethnicity who are in good health. Specific equations must therefore be developed for these populations, as has been done for African-American persons (3).
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