John T. Schousboe, MD, MS; John A. Nyman, PhD; Robert L. Kane, MD; Kristine E. Ensrud, MD, MPH
Potential Financial Conflicts of Interest: Grants received: J.T. Schousboe (Hologic, Inc.), K.E. Ensrud (Eli Lilly & Co., Pfizer, NPB Pharmaceuticals).
Requests for Single Reprints: John T. Schousboe, MD, MS, Park Nicollet Clinic, 3800 Park Nicollet Boulevard, Minneapolis, MN 55416; e-mail, firstname.lastname@example.org.
Current Author Addresses: Dr. Schousboe: Park Nicollet Clinic, 3800 Park Nicollet Boulevard, Minneapolis, MN 55416.
Drs. Nyman and Kane: Division of Health Services Research and Policy, School of Public Health, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455.
Dr. Ensrud: Department of Medicine, Minneapolis Veterans Administration Medical Center, 1 Veterans Drive, Minneapolis, MN 55417.
Author Contributions: Conception and design: J.T. Schousboe, R.L. Kane.
Analysis and interpretation of the data: J.T. Schousboe, J.A. Nyman, K.E. Ensrud.
Drafting of the article: J.T. Schousboe.
Critical revision of the article for important intellectual content: J.T. Schousboe, R.L. Kane, K.E. Ensrud.
Final approval of the article: J.T. Schousboe, R.L. Kane, K.E. Ensrud.
Administrative, technical, or logistic support: J.T. Schousboe, R.L. Kane.
Collection and assembly of data: J.T. Schousboe.
Schousboe JT, Nyman JA, Kane RL, Ensrud KE. Cost-Effectiveness of Alendronate Therapy for Osteopenic Postmenopausal Women. Ann Intern Med. 2005;142:734-741. doi: 10.7326/0003-4819-142-9-200505030-00008
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Published: Ann Intern Med. 2005;142(9):734-741.
Many postmenopausal women have osteopenia but not osteoporosis or fracture history. Information about the cost-effectiveness of treating such women with alendronate should guide clinical recommendations.
The investigators estimate that the costs of treating postmenopausal women with osteopenia (femoral neck T-scores > −2.5) for 5 years with alendronate range from $70 000 to $332 000 per quality-adjusted life-year.
Unless the cost of alendronate decreases or new data show that alendronate reduces fracture risk more than is currently thought, treatment of osteopenia with alendronate costs more than Americans are typically willing to pay for health care interventions.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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