Antonio M. Possolo, PhD
Disclaimer: The analyses and the opinions described in this letter are solely those of the author, were developed by him on his personal time, are unrelated to the work he performs for his employer, and do not purport to represent any views or positions held by his employer (General Electric).
Potential Financial Conflicts of Interest: None disclosed.
Possolo AM. High-Dosage Vitamin E Supplementation and All-Cause Mortality. Ann Intern Med. 2005;143:154. doi: 10.7326/0003-4819-143-2-200507190-00025
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Published: Ann Intern Med. 2005;143(2):154.
TO THE EDITOR:
Given the results of the dose–response analysis summarized in Miller and colleagues' Figure 3 (1), the authors observed that the 95% confidence band for the risk difference does not include 0 for dosages greater than 900 IU/d. They go on (in their Table 2) to derive pooled risk differences and ratios therefrom that suggest a statistically significant relationship between dosage of vitamin E supplementation and all-cause mortality. The authors are to be commended for listing the data they used, thereby facilitating the exploration of alternative analyses. The ability to do this is especially important here because the statistical significance of the observed risk differences is not overwhelming.
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