Rainer Wessely, MD; Adnan Kastrati, MD; Albert Schömig, MD
Wessely R, Kastrati A, Schömig A. Late Restenosis in Patients Receiving a Polymer-Coated Sirolimus-Eluting Stent. Ann Intern Med. 2005;143:392-394. doi: 10.7326/0003-4819-143-5-200509060-00119
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Published: Ann Intern Med. 2005;143(5):392-394.
The first patient received a sirolimus-eluting stent to treat proximal left anterior descending stenosis (part A, white arrow) with an appropriate angiographic follow-up result at 7 months (part B). Later, after 20.4 months, the patient presented with late restenosis in the sirolimus-eluting stent (parts C and D). Of note, a bare-metal stent implanted around the same time did not reveal progressive restenosis (parts A through C, black arrows). The second patient received a sirolimus-eluting stent for treatment of de novo right coronary artery stenosis (part E, arrow) with adequate result at angiographic follow-up at 7 months (part F). Later, after 18.9 months, the patient presented with late restenosis in the sirolimus-eluting stent (parts G and H). Of note, a bare-metal stent implanted around the same time showed regression of in-stent neointima (see Figure 2).
Minimal lumen diameter in bare-metal stents reached the minimum at 7-month follow-up in both patients and increased thereafter. In contrast, minimal lumen diameter steadily decreased in both polymer-coated sirolimus-eluting stents, demonstrating delayed neointimal growth.
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