Akifumi Matsuyama, MD, PhD; Naohiko Sakai, MD, PhD; Masato Ishigami, MD, PhD; Hisatoyo Hiraoka, MD, PhD; Shizuya Yamashita, MD, PhD
Potential Financial Conflicts of Interest: None disclosed.
Matsuyama A., Sakai N., Ishigami M., Hiraoka H., Yamashita S.; Minocycline for the Treatment of Takayasu Arteritis. Ann Intern Med. 2005;143:394-395. doi: 10.7326/0003-4819-143-5-200509060-00021
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Published: Ann Intern Med. 2005;143(5):394-395.
TO THE EDITOR:
Background: Takayasu arteritis is a type of chronic vasculitis that primarily affects large elastic arteries. It tends to progress despite treatment with glucocorticoids or immunosuppressive agents (1, 2). Recently, we reported that matrix metalloproteinases (MMPs) might contribute to the pathogenesis and exacerbation of Takayasu arteritis and that circulating levels of MMPs could be diagnostic markers of the disease (3). While many MMP inhibitors are under development (4), minocycline has established MMP inhibitor activity that is independent of antimicrobial activity (5).
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