Barna D. Tugwell, MD; Priti R. Patel, MD, MPH; Ian T. Williams, PhD, MS; Katrina Hedberg, MD, MPH; Feng Chai, PhD; Omana V. Nainan, PhD; Ann R. Thomas, MD, MPH; Judith E. Woll, MD; Beth P. Bell, MD, MPH; Paul R. Cieslak, MD
Tugwell BD, Patel PR, Williams IT, Hedberg K, Chai F, Nainan OV, et al. Transmission of Hepatitis C Virus to Several Organ and Tissue Recipients from an Antibody-Negative Donor. Ann Intern Med. 2005;143:648-654. doi: 10.7326/0003-4819-143-9-200511010-00008
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Published: Ann Intern Med. 2005;143(9):648-654.
Dates of transplantation for 2 recipients were unknown. Hepatitis C virus infection was diagnosed in 3 recipients in September, October, and November 2001. These recipients had undergone transplantation in February 2001, October 2000, and April 2001, respectively.
Each branch represents a different viral sequence, and small distances between branches suggest genetic relatedness. Sequences belonging to each NHANES III participant and a recipient known to have been infected before transplantation are marked by separate shaded regions. The size of each shaded region represents the genetic diversity of quasi-species from that specimen or group of specimens. Isolates belonging to the donor and 8 case-patients are clustered together.
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Gastroenterology/Hepatology, Infectious Disease, Viral Hepatitis.
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