Anna Wald, MD, MPH; Andria G.M. Langenberg, MD; Elizabeth Krantz, MS; John M. Douglas, MD; H. Hunter Handsfield, MD; Richard P. DiCarlo, MD; Adaora A. Adimora, MD, MPH; Allen E. Izu, MD; Rhoda Ashley Morrow, PhD; Lawrence Corey, MD
Note: This paper was presented in part at the 2002 National STD Prevention Conference, San Diego, California, 4–7 March 2002.
Grant Support: In part by National Institutes of Health Herpes Program Project Grant AI-30731 and Centers for Disease Control and Prevention Prevention Research Initiative UR6/CCU017828-02.
Potential Financial Conflicts of Interest: Employment: A.G.M. Langenberg (Chiron Corp., Corgentech, Inc.), A.E. Izu (Chiron Corp.); Stock ownership or options (other than mutual funds): A.G.M. Langenberg (Chiron Corp.), A.E. Izu (Chiron Corp.); Grants received: R.A. Morrow (Chiron Corp.), L. Corey (Chiron Corp.).
Requests for Single Reprints: Anna Wald, MD, MPH, University of Washington, Virology Research Clinic, 600 Broadway, Suite 400, Seattle, WA 98122; e-mail, email@example.com.
Current Author Addresses: Dr. Wald and Ms. Krantz: University of Washington, Virology Research Clinic, 600 Broadway, Suite 400, Seattle, WA 98122.
Dr. Langenberg: Corgentec, Inc., 650 Gateway Boulevard, South San Francisco, CA 94080.
Dr. Douglas: Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333.
Dr. Handsfield: University of Washington, 325 Ninth Avenue, Seattle, WA 98104.
Dr. DiCarlo: Louisiana University School of Medicine, 2020 Gravier Street, Suite 102, New Orleans, LA 70012.
Dr. Adimora: Division of Infectious Disease, University of North Carolina School of Medicine, CB 7030, Chapel Hill, NC 27599.
Dr. Izu: Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608.
Dr. Morrow: University of Washington, Box 359300-W8814, Seattle, WA 98195.
Dr. Corey: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109.
Author Contributions: Conception and design: A. Wald, A.G.M. Langenberg, A.E. Izu, L. Corey.
Analysis and interpretation of the data: A. Wald, E. Krantz, A.E. Izu, L. Corey.
Drafting of the article: A. Wald, E. Krantz.
Critical revision of the article for important intellectual content: A. Wald, A.G.M. Langenberg, J.M. Douglas Jr, R.P. DiCarlo, R.A. Morrow, L. Corey.
Final approval of the article: A. Wald, A.G.M. Langenberg, E. Krantz, J.M. Douglas Jr., H.H. Handsfield, R.P. DiCarlo, A.A. Adimora, A.E. Izu, R.A. Morrow, L. Corey.
Provision of study materials or patients: J.M. Douglas Jr., H.H. Handsfield, R.P. DiCarlo, A.A. Adimora.
Statistical expertise: E. Krantz.
Obtaining of funding: A. Wald, L. Corey.
Administrative, technical, or logistical support: A. Wald, R.A. Morrow, L. Corey.
Collection and assembly of data: A.G.M. Langenberg, J.M. Douglas Jr., H.H. Handsfield, R.P. DiCarlo, A.A. Adimora, A.E. Izu, R.A. Morrow.
Wald A, Langenberg AG, Krantz E, Douglas JM, Handsfield HH, DiCarlo RP, et al. The Relationship between Condom Use and Herpes Simplex Virus Acquisition. Ann Intern Med. 2005;143:707-713. doi: 10.7326/0003-4819-143-10-200511150-00007
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Published: Ann Intern Med. 2005;143(10):707-713.
We need other means to reduce the risk for transmitting genital herpes (herpes simplex virus type 2 [HSV-2]). Are condoms effective?
In a trial of an ineffective HSV-2 vaccine, 1843 participants were divided into 3 groups according to the frequency of condom use (for 0% to 25%, 25% to 75%, and >75% to 100% of sexual acts). Frequent condom users had fewer HSV-2 infections. Compared with participants in the next lowest category, participants in a category had a 26% lower risk for HSV-2 infection.
In this observational cohort study, many unmeasured factors could also contribute to altered rates of HSV-2 acquisition.
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