Masahide Hamaguchi, MD; Takao Kojima, MD; Noriyuki Takeda, MD; Takayuki Nakagawa, MD; Hiroya Taniguchi, MD; Kota Fujii, MD; Tatsushi Omatsu, MD; Tomoaki Nakajima, MD; Hiroshi Sarui, MD; Makoto Shimazaki, MD; Takahiro Kato, MD; Junichi Okuda, MD; Kazunori Ida, MD
Acknowledgments: The authors thank Chisato Nagata, MD, PhD (Department of Public Health, Gifu University, Gifu, Japan), for reviewing the manuscript and for assistance with the statistical analyses.
Grant Support: None.
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Masahide Hamaguchi, MD, Department of Gastroenterology, Murakami Memorial Hospital, Asahi University, 3-23 Hashimoto-cho, Gifu 500-8523, Japan; e-mail, firstname.lastname@example.org.
Current Author Addresses: Drs. Hamaguchi, Kojima, Nakagawa, Taniguchi, Omatsu, Shimazaki, Kato, Okuda, and Ida: Department of Gastroenterology, Murakami Memorial Hospital, Asahi University, 3-23 Hashimoto-cho, Gifu 500-8523, Japan.
Drs. Takeda and Sarui: Department of Endocrinology and Metabolism, Murakami Memorial Hospital, Asahi University, 3-23 Hashimoto-cho, Gifu 500-8523, Japan.
Drs. Fujii and Nakajima: Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Hirokoji, Kawaramachi, Kamigyo-ku, Kyoto 602-8566, Japan.
Author Contributions: Conception and design: M. Hamaguchi, T. Kojima, N. Takeda.
Analysis and interpretation of the data: M. Hamaguchi, N. Takeda.
Drafting of the article: M. Hamaguchi, N. Takeda.
Critical revision of the article for important intellectual content: M. Hamaguchi, N. Takeda.
Final approval of the article: M. Hamaguchi, T. Kojima, N. Takeda, T. Nakagawa, H. Taniguchi, K. Fujii, T. Omatsu, T. Nakajima, H. Sarui, M. Shimazaki, T. Kato, J. Okuda, K. Ida.
Provision of study materials or patients: T. Kojima, J. Okuda, K. Ida.
Statistical expertise: M. Hamaguchi.
Administrative, technical, or logistic support: T. Kojima, N. Takeda, J. Okuda, K. Ida.
Collection and assembly of data: M. Hamaguchi, T. Kojima, N. Takeda, T. Nakagawa, H. Taniguchi, K. Fujii, T. Omatsu, T. Nakajima, H. Sarui, M. Shimazaki, T. Kato.
Hamaguchi M, Kojima T, Takeda N, Nakagawa T, Taniguchi H, Fujii K, et al. The Metabolic Syndrome as a Predictor of Nonalcoholic Fatty Liver Disease. Ann Intern Med. 2005;143:722-728. doi: 10.7326/0003-4819-143-10-200511150-00009
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Published: Ann Intern Med. 2005;143(10):722-728.
The metabolic syndrome is often present in patients with nonalcoholic fatty liver disease (NAFLD), but no one knows whether it precedes NAFLD.
At baseline, 812 members of a cohort of 4401 apparently healthy Japanese adults had NAFLD on abdominal ultrasonography. In 1 year, the authors identified 308 new cases, and NAFLD had resolved in 113 participants. Participants with the metabolic syndrome were much more likely to develop NAFLD and were less likely to experience disease resolution.
Abdominal ultrasonography is not a perfect gold standard test for NAFLD.
The metabolic syndrome appears to predispose people to develop NAFLD.
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Gastroenterology/Hepatology, Obesity, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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