Giorgos Bamias, MD; Mark R. Nyce, MD; Sarah A. De La Rue, PhD; Fabio Cominelli, MD, PhD
Acknowledgments: The authors thank the entire personnel of the Digestive Health Center of Excellence at the University of Virginia.
Grant Support: By the United States Public Health Service/National Institutes of Health grants DK-42195, DK-44540, and DK-55812 to Fabio Cominelli and The UVa Digestive Health Research Center (P30 DK-67629).
Potential Financial Conflicts of Interest: Honoraria : F. Cominelli (UCB Pharmaceuticals, Inc., Centocor, Elan, Sigma-Tau).
Requests for Single Reprints: Fabio Cominelli, MD, PhD, Division of Gastroenterology and Hepatology, P.O. Box 800708, University of Virginia Health System, Charlottesville, VA 22908; e-mail, firstname.lastname@example.org.
Current Author Addresses: Drs. Bamias, Nyce, De La Rue, and Cominelli: Digestive Health Center of Excellence, University of Virginia, P.O. Box 800708, Charlottesville, VA 22908-0708.
Bamias G, Nyce MR, De La Rue SA, Cominelli F. New Concepts in the Pathophysiology of Inflammatory Bowel Disease. Ann Intern Med. 2005;143:895-904. doi: 10.7326/0003-4819-143-12-200512200-00007
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Published: Ann Intern Med. 2005;143(12):895-904.
The inflammatory bowel diseases (IBDs), that is, Crohn disease and ulcerative colitis, affect approximately 1 million persons in North America and several million persons worldwide.
Approximately 30% of patients present between 10 and 30 years of age.
Current therapeutic options are limited and include nonspecific anti-inflammatory and immunosuppresive medications.
Surgery is required for 50% to 80% of patients with Crohn disease, while only 20% of patients with ulcerative colitis have surgery.
Novel biological therapeutics have greatly improved the quality of life of patients with IBD.
Both genetic and environmental factors play important roles in disease pathogenesis.
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Gastroenterology/Hepatology, Inflammatory Bowel Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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