Mary McGrae McDermott, MD; Kiang Liu, PhD; Luigi Ferrucci, MD, PhD; Michael H. Criqui, MD, MPH; Philip Greenland, MD; Jack M. Guralnik, MD, PhD; Lu Tian, ScD; Joseph R. Schneider, MD, PhD; William H. Pearce, MD; Jin Tan, MS; Gary J. Martin, MD
Potential Financial Conflicts of Interest: None disclosed.
Grant Support: By the National Heart, Lung, and Blood Institute (grant numbers R01-HL58099 and R01-HL64739) and by the National Center for Research Resources, National Institutes of Health (grant number RR-00048).
Requests for Single Reprints: Mary M. McDermott, MD, 675 North St. Clair, Suite 18-200, Chicago, IL 60611; e-mail, email@example.com.
Current Author Addresses: Drs. McDermott and Martin: 675 North St. Clair, Suite 18-200, Chicago, IL 60611.
Drs. Liu, Greenland, and Tian and Mr. Tan: 680 N. Lake Shore Drive, Suite 1102, Chicago, IL 60611.
Dr. Ferrucci: National Institute on Aging, Clinical Research Branch, Harbor Hospital, 3001 South Hanover Street, Fifth Floor, Baltimore, MD 21225.
Dr. Criqui: University of California at San Diego, Family & Preventive Medicine, 9500 Gilman Drive, La Jolla, CA 92093.
Dr. Guralnik: National Institute on Aging, Gateway Building, Room 3-C309, 7201 Wisconsin Avenue, Bethesda, MD 20892.
Dr. Schneider: Evanston Northwestern Hospital, Department of Surgery, 2650 Ridge Avenue, Burch 100, Evanston, IL 60201.
Dr. Pearce: 201 East Huron, Suite 10-105, Chicago, IL 60611.
Author Contributions: Conception and design: M.M. McDermott, K. Liu, L. Ferrucci, P. Greenland, J.M. Guralnik, J.R. Schneider, G.J. Martin.
Analysis and interpretation of the data: M.M. McDermott, K. Liu, L. Ferrucci, M.H. Criqui, P. Greenland, J.M. Guralnik, L. Tian, J. Tan, G.J. Martin.
Drafting of the article: M.M. McDermott, M.H. Criqui.
Critical revision of the article for important intellectual content: M.M. McDermott, L. Ferrucci, M.H. Criqui, P. Greenland, J.M. Guralnik, J.R. Schneider, G.J. Martin.
Final approval of the article: M.M. McDermott, K. Liu, M.H. Criqui, P. Greenland, J.M. Guralnik, L. Tian, J.R. Schneider, W.H. Pearce, J. Tan, G.J. Martin.
Provision of study materials or patients: J.R. Schneider, W.H. Pearce, G.J. Martin.
Statistical expertise: K. Liu, L. Tian.
Obtaining of funding: M.M. McDermott, K. Liu, M.H. Criqui, G.J. Martin.
Administrative, technical, or logistic support: W.H. Pearce, J. Tan.
Collection and assembly of data: M.M. McDermott, W.H. Pearce.
McDermott MM, Liu K, Ferrucci L, Criqui MH, Greenland P, Guralnik JM, et al. Physical Performance in Peripheral Arterial Disease: A Slower Rate of Decline in Patients Who Walk More. Ann Intern Med. 2006;144:10-20. doi: 10.7326/0003-4819-144-1-200601030-00005
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Published: Ann Intern Med. 2006;144(1):10-20.
Peripheral arterial disease (PAD) of the lower extremities affects 20% to 30% of older patients in general medical practices (1, 2). Most patients with the disease do not have classical symptoms of intermittent claudication (1-3). Compared with those without PAD, persons with the disease have significantly greater functional impairment and more rapid functional decline (2-4). Exercise rehabilitation that includes supervised treadmill walking substantially improves treadmill walking performance in men and women with intermittent claudication (5). However, such barriers as cost, transportation, and program availability often limit access to exercise rehabilitation programs for patients with PAD (6, 7).
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Cardiology, Nephrology, Hypertension, Coronary Risk Factors.
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