Lewis J. Rubin, MD; David B. Badesch, MD
Potential Financial Conflicts of Interest: None disclosed.
Rubin LJ, Badesch DB. Thyrotoxicosis as a Risk Factor for Pulmonary Arterial Hypertension. Ann Intern Med. 2006;144:222-223. doi: 10.7326/0003-4819-144-3-200602070-00023
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Published: Ann Intern Med. 2006;144(3):222-223.
We agree with Drs. Ma and Chow that there is some justification for screening patients with PAH for thyroid dysfunction. We were among the first to make the observation that thyroid abnormalities might occur with increased frequency in patients with PAH (1). In that report, we speculated that there might be a common underlying autoimmune disorder. The concept that antithyroid antibodies could play a role in the pathogenesis of PAH is indeed quite intriguing, and there have been several subsequent reports of hypothyroidism and hyperthyroidism occurring in patients with pulmonary hypertension (2-5), although a causal relationship has not been proven.
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