Margaret V. Ragni, MD, MPH; Steven H. Belle, PhD; KyungAh Im, BS; John Fung, MD, PhD; Guy Neff, MD; Michelle Roland, MD; Peter Stock, MD; Nigel Heaton, MD; Abhi Humar, MD
Potential Financial Conflicts of Interest: None disclosed.
Ragni M., Belle S., Im K., Fung J., Neff G., Roland M., Stock P., Heaton N., Humar A.; Liver Transplantation in HIV-Seropositive Individuals. Ann Intern Med. 2006;144:223. doi: 10.7326/0003-4819-144-3-200602070-00024
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Published: Ann Intern Med. 2006;144(3):223.
TO THE EDITOR:
We were pleased that our recent paper (1) concerning liver transplantation in HIV-infected individuals was chosen for the 2005 Update in Gastroenterology and Hepatology (2), but we would like to clarify a few points about our paper and this evolving field.
Contrary to the review by Drs. Koretz and Lipman, this was a prospective study of consecutively enrolled HIV-seropositive liver transplant recipients who underwent the procedure according to the same listing criteria as HIV-seronegative recipients. We felt compelled to carry out this study because 1) significant advances had occurred in the area of highly active antiretroviral therapy (HAART), 2) HIV-seropositive individuals were surviving with AIDS only to die of end-stage liver disease (3), and 3) our past studies had suggested that liver transplantation was unsafe because of the immunodeficiency associated with antirejection immunotherapy and with HIV infection (before the advent of HAART) (4).
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