Andre C. Kalil, MD; Elizabeth Lyden, MS; Julie Stoner, PhD
Potential Financial Conflicts of Interest: None disclosed.
Kalil AC, Lyden E, Stoner J. Controlling the Troll. Ann Intern Med. 2006;144:457-458. doi: 10.7326/0003-4819-144-6-200603210-00026
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Published: Ann Intern Med. 2006;144(6):457-458.
TO THE EDITOR:
We read Dr. Dummer's editorial (1) about our study (2) with interest. However, we would like to make some clarifications.
We agree with Dr. Dummer's recommendation that because of potential confounding factors related to differing outcomes in the preemptive and prophylactic trials, “it would be unwise to directly compare the results achieved with the 2 strategies.” Our study made no such formal, direct comparisons. In the Discussion section, we clearly stated that comparison of these 2 approaches needs to be based on a “prospective trial directly comparing universal prophylaxis with a preemptive approach.”
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